A centrifugal-based filter is a filtration device that uses centrifugal force to separate particles or molecules from a solution. The sample is placed in a filter unit and spun at high speeds in a centrifuge, which causes the particles to either collect at the bottom of the filter or pass through a membrane. This method is commonly used for concentrating samples, removing contaminants, or separating biological macromolecules, such as proteins or nucleic acids, from solvents.